Cellular Immunology Laboratory
Department of Zoology, UoB
Research
Our mission is to unravel the intricate dynamics between the immune system and cancer, propelling us towards innovative therapeutic strategies.
Converting a Cold Tumor to a Hot Tumor: Targeting cancer dependencies to Overcome immune supression and developed novel Immunotherapies against Cancer
The presented proposal aims to optimize the effectiveness of immunotherapy in treating colon cancer by addressing critical cancer dependencies such as TGF-beta, STATs and TYMP. These dependencies play a pivotal role in the progression of colon cancer and the development of the cold tumor phenotype. Cold tumors, characterized by limited T-cell infiltration, often exhibit a suboptimal response to immunotherapy. In contrast, hot tumors, characterized by significant immune cell infiltration, tend to respond more favorably to treatment.
This initiative encompasses a strategic application of inhibitors or genetic manipulation to specifically target cancer dependencies, with the goal of amplifying T-cell infiltration and converting cold tumors into a more responsive, hot tumor state. Through comprehensive in vitro and in vivo studies, we aim to evaluate the impact of inhibiting cancer dependencies on T-cell activation, proliferation, and antitumor activity using preclinical models of colon cancer. Additionally, the project will investigate potential synergistic effects by exploring combinations with other immunotherapeutic approaches. The overarching objective of this research is to advance treatment outcomes for individuals with colon cancer, thereby broadening the scope and effectiveness of immunotherapies.
Targeting nucleoside metabolism in the tumor microenvironment to maintain the effector function of T cells in colon cancer
Fight against colon cancer is hard because a hostile environment weakens our body's natural cancer-fighting ability. Our team is researching on an enzyme, Thymidine Phosphorylase (TP), which is more common in colon cancer and helps it grow. We're exploring its connection to a protein, Neuropilin-1 (NRP1), that promotes blood vessels development and affects the functionality of our defence cells. We aim to understand how TP interacts with NRP1 and our immune system's. We're looking for ways to make chemotherapy more effective by reducing the obstacles to our immune system. Ultimately, we hope to improve outcomes for colon cancer patients
